![]() ![]() S/he may repeatedly lose consciousness and the infected area will swell to several times the normal size. If NF progresses to show critical symptoms, the patient’s confusion and weakness will become pronounced and the patient may become delirious. The patient may have extremely low blood pressure (hypotension) and a faint, rapid heartbeat (tachycardia), which results in dizziness, weakness, and confusion. This may occur as the nerves to the area begin to die. Although the pain becomes excruciating over the initial 12-48 hours, a very late sign of infection is sudden improvement in pain or lack of sensation in the affected area. The affected area may become hard due to the swelling/inflammation caused by the infection (induration). As the infection progresses, the affected area will continue to swell, become purple or mottled (blotches of black, purple, and red), and may be accompanied by a rash of blisters and this is a sign of skin necrosis. The infected area may appear bright red, shiny, swollen, and very hot to the touch. The pain in the infected area becomes constant and piercing, much more severe than the original injury would dictate. If NF progresses to show advanced symptoms, the patient will continue to have a very high fever (over 104 degrees Fahrenheit) or may become hypothermic (low temperature) and become dehydrated. The affected area may also spread from the infection point quickly, sometimes spreading at a rate of an inch an hour. The red area often occurs at the infection point, which may include surgical sites, a cut, scratch, bruise, boil, site of medication or drug injection, or any small injury that could have occurred during daily life. Around the same time, patients may notice redness (erythema) and pain or tenderness around the red area. They include high fever, sore throat, stomach ache, nausea, diarrhea, chills, and general body aches. Stay Informed With NORD’s Email NewsletterĮarly symptoms of NF are often mistaken for the flu.Find a Rare Disease Patient Organization.Rare Disease Cures Accelerator (RDCA-DAP).Find Clinical Trials & Research Studies.Launching Registries & Natural History Studies.A Podcast For The Rare Disease Community. ![]()
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